Hepatitis C Virus Infection during Pregnancy in Upper Egypt
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Author(s)
Abstract
Background: It is estimated that 150–200 million people, or 3% of the world's population, are living with chronic hepatitis C. Objective: to identify the prevalence of HCV among pregnant women and infants of infected women and detect risk factors and the rate of vertical transmission.Methods: 3000 births of pregnant women aged between 18 to 43 years were randomized and prospectively screened using HCV antibody and HCV polymerase chain reaction (PCR) analysis to identify the risk of pregnancy on HCV and HCV on pregnancy and the prevalence of HCV among pregnant women and infants of infected women to identify the rate of vertical transmission.Results: A total of 3000 pregnant women attending perinatal care were screened. Forty four (1. 46%) showed HCV-positive antibodies, vertical transmission (13.6%) and six (0.2%) of newborns tested positive within the first 24 hours post-delivery. Three-fourth (33/44) of the HCV positive pregnant women had a history of surgical intervention. However, 50% (22/44) had history of Cesarean section and blood transfusion (11/44).Conclusion: The prevalence of HCV in pregnant women in Egypt is lower than previously reported. Risk factors for transmission suggest that there is a correlation between the age and parity of the studied women and the incidence of hepatitis C infection. Hepatitis C virus infection was found more among those women with past history of previous surgery or blood transfusion. Further studies are needed to explore this issue. Incidence of vertical transmission of HCV in Egypt is not more different than in other countries and it plays no role in the high endemicity in Egyp
Keywords
Hepatitis C virus, vertical transmission, pregnant women.
Cite this paper
Mahmoud Edessy, Abd El Aziz G. Al Darwish, Hosam H. El Katatny, Manal G. Abd El Aty, Ahmed Abd El Hamed, Osama Abd El Azeem,
Hepatitis C Virus Infection during Pregnancy in Upper Egypt
, SCIREA Journal of Clinical Medicine.
Volume 1, Issue 1, October 2016 | PP. 97-109.
References
[ 1 ] | AbdulQawi K, Youssef A, Metwally MA, Ragih I, AbdulHamid M, Shaheen A (2010): Prospective study of prevalence and risk factors for hepatitis C in pregnant Egyptian women and its transmission to their infants. CroatMed J 51; 219–228. |
[ 2 ] | Floreani, Annarosa. "Hepatitis C and pregnancy." World J Gastroenterol19.40 (2013): 6714-20. |
[ 3 ] | Armstrong GL, Wasley A, Simard EP, McQuillan GM, Kuhnert WL and Alter MJ (2006):The prevalence of hepatitis C virus infection in the United States, 1999 through 2002. Ann Intern Med; 144; 705–714. |
[ 4 ] | El-Ghazaly H, El-Kamary SS, Hashem M, Saleh DA, Ehab M, Sharaf SA, El-Mougy F, Abdelsalam L, Jhaveri R, Aboulnasr A (2015): Reliability of risk-based screening for hepatitis C virus infection among pregnant women in Egypt. J Infect. 70(5):512-519. |
[ 5 ] | Goyal LD, Kaur S, Jindal N, Kaur H:(2014).HCV and pregnancy: prevalence, risk factors, and pregnancy outcome in north Indian population: a case-control study .J Obstet Gynaecol India. |
[ 6 ] | Hayashida A, Inaba N, Oshima K, Nishikawa M, Shoda A, Hayashida S, et al(2007): Re-evaluation of the true rate of hepatitis C virus mother-to-child transmission and its novel risk factors based on our two prospective studies. J Obstet Gynaecol Res. 33:417–422. |
[ 7 ] | Heintges T and Wands JR (1997): Hepatitis C virus: epidemiology and transmission. Hepatology; 526:521. |
[ 8 ] | Khamis HH, Farghaly AG, Shatat HZ, El-Ghitany EM: (2014).Prevalence of hepatitis C virus infection among pregnant women in a rural district in Egypt |
[ 9 ] | Lozano R (2012): Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010". Lancet 380; 2095–2128. |
[ 10 ] | Mahmoud Edessy, Ahmed A.M. Nasr, Abd ElRaouf Oun and Younes El-Said (2015): Hepatitis C Virus Infection during pregnancy in Delta Egypt. International Journal of Advanced Research in Biological Sciences. Research Article ISSN : 2348-8069. |
[ 11 ] | Mohd Hanafiah K, Groeger J, Flaxman AD,Wiersma ST. (2013): Global epidemiology of hepatitis C virus infection new estimates of age-specific antibody to HCV seroprevalence. Hepatology. 57:1333–1342. |
[ 12 ] | Ramachandran P, Fraser A, Agarwal K, et al (2012): UK consensus guidelines for the use of the protease inhibitors boceprevir and telaprevir in genotype 1 chronic hepatitis C infected patients. Aliment Pharmacol Ther. 35; 647. |
[ 13 ] | Stoszek SK, Abdel-Hamid M, Narooz S, El Daly M, Saleh DA, Mikhail N, Kassem E, Hawash Y, El Kafrawy S, Said A, et al (2006): Prevalence of and risk factors for hepatitis C in rural pregnant Egyptian women. Trans R Soc Trop Med Hyg.100:102–107. |
[ 14 ] | Mahmoud Edessy, Ahmed A.M. Nasr, Abd El Raouf Oun and Younes El-Said :Hepatitis C Virus Infection during pregnancy in Delta Egypt Int. J. Adv. Res. Biol.Sci. 2(4): (2015): 83–91 |