Synthesis of hydrofluoroethers (HFEs) as alternatives to CFCs

Volume 3, Issue 2, April 2018     |     PP. 13-24      |     PDF (430 K)    |     Pub. Date: September 25, 2018
DOI:    1361 Downloads     7914 Views  

Author(s)

Wei Li, Beijing Institute of Technology, 5 South Zhongguangcun Street, Haidian District, Beijing, 100081, P.R. China; Zhejiang Chemical Industry Research Institute Co., Ltd., Hangzhou 310023, P.R. China.
Zhikai Guo, Zhejiang Chemical Industry Research Institute Co., Ltd., Hangzhou 310023, P.R. China.
Hengdao Quan, Beijing Institute of Technology, 5 South Zhongguangcun Street, Haidian District, Beijing, 100081, P.R. China.

Abstract
A facile synthetic route for the preparation of a series of hydrofluoroethers (HFEs) was developed. This route was based on two key reactions. The first reaction involved the alcoholysis of various fluoroalcohols with p-toluenesulfonyl chloride in a sodium hydroxide solution, while the second involved the Williamson ether syntheses of the desired HFEs from the corresponding tosylates using sodium methoxide in methanol. As a result, a range of HFEs were synthesized using this mild and efficient method.

Keywords
hydrofluoroethers • alcoholysis • Williamson ether synthesis

Cite this paper
Wei Li, Zhikai Guo, Hengdao Quan, Synthesis of hydrofluoroethers (HFEs) as alternatives to CFCs , SCIREA Journal of Chemistry. Volume 3, Issue 2, April 2018 | PP. 13-24.

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